Archbishop Patrick Cronin, SSC, DD succeeded Archbishop Hayes in 1972 and continued his legacy of compassion for the sick, poor, and the needy. He was then replaced by Most Rev. Jesus B. Tuquib, DD who automatically assumed the Chair of the Maria Reyna Hospital Board of Trustees. On its 25th Anniversary in 1983, different activities were organized throughout the year. Departmentalization of medical practice formally began in 1993 with residency training program in Internal Medicine, Pediatrics, Surgery, Obstetrics and Gynecology. Maria Reyna Hospital continued to be the affiliating hospital of Nursing students. In 2005, Archbishop Jesus B. Tuquib, DD retired at the age of 76 and the Archdiocese welcomed its new shepherd in the person of his Excellency Most Rev, Antonio Ledesma, SJ, DD who also assumed the chair of the Board of Trustees.

Desiring to expand its services in order to serve more people in need of quality and affordable health care, the Board of Trustees decided to venture into a breaking through partnership in the history of SPC Hospital Administration and of the Archdiocese of Cagayan de Oro where the Maria Reyna Hospital is concerned. In June 29, 2010, The Archdiocese of Cagayan de Oro, The Sisters of St. Paul of Chartres, and Xavier University – Ateneo de Cagayan forged a tripartite partnership and signed the Memorandum of Agreement as the new owners of the hospital. With the change in the nature of ownership of the hospital came also the inevitable change of name. With the hospital as now the base hospital for the College of Medicine and Nursing of Xavier University, the Security of Exchange Commission approved the new name of the hospital in April 8, 2011 as the now Maria Reyna – Xavier University Hospital, Inc.